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1

Development and validation of an assay for the quantification of 11 nucleotides using LC/LC–electrospray ionization–MS

Jost Klawitter, Volker Schmitz, Jelena Klawitter, Dieter Leibfritz, Uwe Christians

Journal:

Analytical Biochemistry

Année:

2007

Langue:

english

Fichier:

PDF, 582 KB

english, 2007

2

Depressed prostaglandins and leukotrienes in veterans with Gulf War illness

Golomb, Beatrice Alexandra, Koslik, Hayley J., Christians, Uwe, Ritchie, Janis, Wilson, Paul, Elkins, Nancy, Klawitter, Jelena, Klawitter, Jost, Smith, Dwight, Repine, John E.

Journal:

Journal of Environmental Science and Health Part B

Année:

2019

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2019

3

Depressed prostaglandins and leukotrienes in veterans with Gulf War illness

Golomb, Beatrice Alexandra, Koslik, Hayley J., Christians, Uwe, Ritchie, Janis, Wilson, Paul, Elkins, Nancy, Klawitter, Jelena, Klawitter, Jost, Smith, Dwight, Repine, John E.

Journal:

Journal of Environmental Science and Health Part B

Année:

2019

Fichier:

PDF, 1.50 MB

2019

4

Prospective evaluation of oral cannabis extracts in children with epilepsy

Knupp, Kelly G., Rice, John D., Helmkamp, Laura J., Galinkin, Jeffrey, Sempio, Cristina, Jost, Klawitter, Chapman, Kevin E.

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 241 KB

english, 2019

5

An Approach to Biomarker Discovery of Cannabis Use Utilizing Proteomic, Metabolomic, and Lipidomic Analyses

Hinckley, Jesse D., Saba, Laura, Raymond, Kristen, Bartels, Karsten, Klawitter, Jost, Christians, Uwe, Hopfer, Christian

Journal:

Cannabis and Cannabinoid Research

Année:

2020

Fichier:

PDF, 588 KB

2020

6

Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture

Jelena Klawitter, Yan Ling Zhang, Jost Klawitter, Nora Anderson, Natalie J. Serkova, Uwe Christians

Journal:

Biomedical Chromatography

Année:

2009

Langue:

english

Fichier:

PDF, 443 KB

english, 2009

7

Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: A combined proteomic and metabolomic study

Jelena Klawitter, Jost Klawitter, Jennifer Gurshtein, Kyler Corby, Sylvia Fong, Mary Tagliaferri, Linda Quattrochi, Isaac Cohen, Emma Shtivelman, Uwe Christians

Journal:

International Journal of Cancer

Année:

2011

Langue:

english

Fichier:

PDF, 1.19 MB

english, 2011

8

Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns

Tobin Strom, Touraj Shokati, Jost Klawitter, Jelena Klawitter, Keith Hoffman, Hans-Martin Schiebel, Uwe Christians

Journal:

Journal of Mass Spectrometry

Année:

2011

Langue:

english

Fichier:

PDF, 313 KB

english, 2011

9

Quantification of 15-F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared

Jelena Klawitter, Manuel Haschke, Touraj Shokati, Jost Klawitter, Uwe Christians

Journal:

Rapid Communications in Mass Spectrometry

Année:

2011

Langue:

english

Fichier:

PDF, 200 KB

english, 2011

10

Organ-specific response to inhibition of mitochondrial metabolism by cyclosporine in the rat

Natalie Serkova, Jost Klawitter, ClausU. Niemann

Journal:

Transplant International

Année:

2003

Langue:

english

Fichier:

PDF, 286 KB

english, 2003

11

Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose

Jost Klawitter, Manuel Haschke, Christine Kahle, Colleen Dingmann, Jelena Klawitter, Dieter Leibfritz, Uwe Christians

Journal:

British Journal of Clinical Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2010

12

Organ-specific response to inhibition of mitochondrial metabolism by cyclosporine in the rat

Natalie Serkova, Jost Klawitter, Claus U. Niemann

Journal:

Transplant International

Année:

2003

Langue:

english

Fichier:

PDF, 923 KB

english, 2003

13

Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells

Jelena Klawitter, Douglas J Kominsky, Jaimi L Brown, Jost Klawitter, Uwe Christians, Dieter Leibfritz, Junia V Melo, S Gail Eckhardt, Natalie J Serkova

Journal:

British Journal of Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 614 KB

english, 2009

14

1H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants

Serkova, Natalie, Fuller, T. Florian, Klawitter, Jost, Freise, Chris E., Niemann, Claus U.

Journal:

Kidney International

Année:

2005

Langue:

english

Fichier:

PDF, 255 KB

english, 2005

15

A high-throughput U-HPLC–MS/MS assay for the quantification of mycophenolic acid and its major metabolites mycophenolic acid glucuronide and mycophenolic acid acyl-glucuronide in human plasma and urine

Jacek Klepacki, Jelena Klawitter, Jamie Bendrick-Peart, Bjorn Schniedewind, Svenja Heischmann, Touraj Shokati, Uwe Christians, Jost Klawitter

Journal:

Journal of Chromatography B

Année:

2012

Langue:

english

Fichier:

PDF, 568 KB

english, 2012

16

Absence of equilibrative nucleoside transporter 1 in ENT1 knockout mice leads to altered nucleoside levels following hypoxic challenge

Jennifer B. Rose, Zlatina Naydenova, Andrew Bang, Azza Ramadan, Jost Klawitter, Kristin Schram, Gary Sweeney, Almut Grenz, Holger Eltzschig, James Hammond, Doo-Sup Choi, Imogen R. Coe

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2011

17

Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice

Grenz, Almut, Bauerle, Jessica D., Dalton, Julee H., Ridyard, Douglas, Badulak, Alexander, Tak, Eunyoung, McNamee, Eóin N., Clambey, Eric, Moldovan, Radu, Reyes, German, Klawitter, Jost, Ambler, Kelly

Journal:

Journal of Clinical Investigation

Année:

2012

Langue:

english

Fichier:

PDF, 2.32 MB

english, 2012

18

Mass spectrometry-based multiplexing for the analysis of biomarkers in drug development and clinical diagnostics — How much is too much?

Uwe Christians, Jacek Klepacki, Touraj Shokati, Jost Klawitter, Jelena Klawitter

Journal:

Microchemical Journal

Année:

2012

Langue:

english

Fichier:

PDF, 487 KB

english, 2012

19

Development and validation of an LC-MS/MS assay for the quantification of the trans-methylation pathway intermediates S-adenosylmethionine and S-adenosylhomocysteine in human plasma

Klepacki, Jacek, Brunner, Nina, Schmitz, Volker, Klawitter, Jelena, Christians, Uwe, Klawitter, Jost

Journal:

Clinica Chimica Acta

Année:

2013

Langue:

english

Fichier:

PDF, 554 KB

english, 2013

20

A Metabonomic and Proteomic Analysis of Changes in IMCD3 Cells Chronically Adapted to Hypertonicity

Klawitter, Jost, Rivard, Christopher J., Brown, Lewis M., Capasso, Juan M., Almeida, Nestor E., Maunsbach, Arvid B., Pihakaski-Maunsbach, Kaarina, Berl, Tomas, Leibfritz, Dieter, Christians, Uwe, Chan

Journal:

Nephron Physiology

Année:

2008

Langue:

english

Fichier:

PDF, 406 KB

english, 2008

21

Impact of Organ Preservation Using HTK for Graft Flush and Subsequent Storage in UW in Rat Kidney Transplantation

Schmitz, Volker, Klawitter, Jost, Bendrick-Peart, Jamie, Haschke, Manuel, Beckey, Virginia E., Laudi, Sven, Neumann, Ulf, Schoening, Wenzel, Neuhaus, Peter, Christians, Uwe, Puhl, Gero

Journal:

European Surgical Research

Année:

2006

Langue:

english

Fichier:

PDF, 551 KB

english, 2006

22

Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease

Klawitter, Jelena, Zafar, Iram, Klawitter, Jost, Pennington, Alexander T, Klepacki, Jacek, Gitomer, Berenice Y, Schrier, Robert W, Christians, Uwe, Edelstein, Charles L

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 294 KB

english, 2013

23

Association of Immunosuppressant-Induced Protein Changes in the Rat Kidney with Changes in Urine Metabolite Patterns: A Proteo-Metabonomic Study

Klawitter, Jost, Klawitter, Jelena, Kushner, Erich, Jonscher, Karen, Bendrick-Peart, Jamie, Leibfritz, Dieter, Christians, Uwe, Schmitz, Volker

Journal:

Journal of Proteome Research

Année:

2010

Langue:

english

Fichier:

PDF, 2.14 MB

english, 2010

24

Low-Salt Diet and Cyclosporine Nephrotoxicity: Changes in Kidney Cell Metabolism

Klawitter, Jelena, Klawitter, Jost, Schmitz, Volker, Brunner, Nina, Crunk, Amanda, Corby, Kyler, Bendrick-Peart, Jamie, Leibfritz, Dieter, Edelstein, Charles L., Thurman, Joshua M., Christians, Uwe

Journal:

Journal of Proteome Research

Année:

2012

Langue:

english

Fichier:

PDF, 2.72 MB

english, 2012

25

Urine Metabolites Reflect Time-Dependent Effects of Cyclosporine and Sirolimus on Rat Kidney Function

Klawitter, Jost, Bendrick-Peart, Jamie, Rudolph, Birgit, Beckey, Virginia, Klawitter, Jelena, Haschke, Manuel, Rivard, Christopher, Chan, Laurence, Leibfritz, Dieter, Christians, Uwe, Schmitz, Volker

Journal:

Chemical Research in Toxicology

Année:

2009

Langue:

english

Fichier:

PDF, 9.16 MB

english, 2009

26

Proteomics and metabolomics in renal transplantation-quo vadis?

Bohra, Rahul, Klepacki, Jacek, Klawitter, Jelena, Klawitter, Jost, Thurman, Joshua M., Christians, Uwe

Journal:

Transplant International

Année:

2013

Langue:

english

Fichier:

PDF, 202 KB

english, 2013

27

Biomarkers of immunosuppressant organ toxicity after transplantation: status, concepts and misconceptions

Christians, Uwe, Klawitter, Jost, Klawitter, Jelena, Brunner, Nina, Schmitz, Volker

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Année:

2011

Langue:

english

Fichier:

PDF, 612 KB

english, 2011

28

A high-performance liquid chromatography – tandem mass spectrometry – based targeted metabolomics kidney dysfunction marker panel in human urine

Klepacki, Jacek, Klawitter, Jost, Klawitter, Jelena, Thurman, Joshua M., Christians, Uwe

Journal:

Clinica Chimica Acta

Année:

2015

Langue:

english

Fichier:

PDF, 474 KB

english, 2015

29

Everolimus and sirolimus in transplantation-related but different

Klawitter, Jost, Nashan, Björn, Christians, Uwe

Journal:

Expert Opinion on Drug Safety

Année:

2015

Langue:

english

Fichier:

PDF, 858 KB

english, 2015

30

Fatty acid desaturation index in human plasma: comparison of different analytical methodologies for the evaluation of diet effects

Klawitter, Jost, Bek, Stephan, Zakaria, Marjorie, Zeng, Chenhui, Hornberger, Andrea, Gilbert, Richard, Shokati, Touraj, Klawitter, Jelena, Christians, Uwe, Boernsen, K. Olaf

Journal:

Analytical and Bioanalytical Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 335 KB

english, 2014

31

Metabolic Profiles in Urine Reflect Nephrotoxicity of Sirolimus and Cyclosporine following Rat Kidney Transplantation

Schmitz, Volker, Klawitter, Jost, Bendrick-Peart, Jamie, Schoening, Wenzel, Puhl, Gero, Haschke, Manuel, Klawitter, Jelena, Consoer, Jeff, Rivard, Christopher J., Chan, Laurence, Tran, Zung V., Leibfr

Journal:

Nephron Experimental Nephrology

Année:

2009

Langue:

english

Fichier:

PDF, 367 KB

english, 2009

32

How Unbiased is Non-Targeted Metabolomics and is Targeted Pathway Screening the Solution?

Christians, Uwe, Klawitter, Jelena, Hornberger, Andrea, Klawitter, Jost

Journal:

Current Pharmaceutical Biotechnology

Année:

2011

Langue:

english

Fichier:

PDF, 485 KB

english, 2011

33

Amino Acids in a Targeted Versus a Non-Targeted Metabolomics LC-MS/MS Assay. Are the Results Consistent?

Klepacki, Jacek, Klawitter, Jost, Klawitter, Jelena, Karimpour-fard, Anis, Thurman, Joshua, Ingle, Gordon, Patel, Dharmesh, Christians, Uwe

Journal:

Clinical Biochemistry

Année:

2016

Langue:

english

Fichier:

PDF, 488 KB

english, 2016

34

Biomarkers of immunosuppressive drug toxicity

Christians, Uwe, Reisdorph, Nichole, Klawitter, Jost, Schmitz, Volker

Journal:

Current Opinion in Organ Transplantation

Année:

2005

Langue:

english

Fichier:

PDF, 118 KB

english, 2005

35

Biomarkers in Transplantation—Proteomics and Metabolomics

Christians, Uwe, Klawitter, Jelena, Klawitter, Jost

Journal:

Therapeutic Drug Monitoring

Année:

2016

Langue:

english

Fichier:

PDF, 98 KB

english, 2016

36

Toxicodynamic Therapeutic Drug Monitoring of Immunosuppressants: Promises, Reality, and Challenges

Christians, Uwe, Schmitz, Volker, Schöning, Wenzel, Bendrick-Peart, Jamie, Klawitter, Jelena, Haschke, Manuel, Klawitter, Jost

Journal:

Therapeutic Drug Monitoring

Année:

2008

Langue:

english

Fichier:

PDF, 246 KB

english, 2008

37

Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches

Checkley, William, Deza, Maria P., Klawitter, Jost, Romero, Karina M., Klawitter, Jelena, Pollard, Suzanne L., Wise, Robert A., Christians, Uwe, Hansel, Nadia N.

Journal:

Respiratory Medicine

Année:

2016

Langue:

english

Fichier:

PDF, 1.32 MB

english, 2016

38

Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart

Klawitter, Jelena, Seres, Tamas, Pennington, Alexander, Beatty, Jonathan-Thomas, Klawitter, Jost, Christians, Uwe

Journal:

Journal of Cellular Biochemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2017

39

Metabolic markers for differentiation between renal allograft rejection and immunosuppressant toxicity in rat urine

Schoening, Wenzel, Schmitz, Volker, Klawitter, Jelena, Christians, Uwe, Klawitter, Jost

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 1.29 MB

english, 2017

40

Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney

Klawitter, Jelena, Pennington, Alexander, Klawitter, Jost, Thurman, Joshua M., Christians, Uwe

Journal:

Scientific Reports

Année:

2017

Langue:

english

Fichier:

PDF, 5.34 MB

english, 2017

41

Bone marrow-derived cPLA2α contributes to renal fibrosis progression

Montford, John R., Lehman, Allison M. B., Bauer, Colin D., Klawitter, Jelena, Klawitter, Jost, Poczobutt, Joanna M., Scobey, Micah, Weiser-Evans, Mary, Nemenoff, Raphael A., Furgeson, Seth B.

Journal:

The Journal of Lipid Research

Année:

2018

Langue:

english

Fichier:

PDF, 1.81 MB

english, 2018

42

Assessment of Tacrolimus Intra-patient Variability in Stable Adherent Transplant Recipients: Establishing Baseline Values

Leino, Abbie D., King, Eileen C., Jiang, Wenlei, Vinks, Alexander A., Klawitter, Jost, Christians, Uwe, Woodle, E.Steve, Alloway, Rita R., Rohan, Jennifer M.

Journal:

American Journal of Transplantation

Année:

2018

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2018

43

Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia

Timic Stamenic, Tamara, Feseha, Simon, Valdez, Robert, Zhao, Wanzhu, Klawitter, Jost, Todorovic, Slobodan M

Journal:

Cerebral Cortex

Année:

2019

Fichier:

PDF, 1.58 MB

2019

44

Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy

Wang, George Sam, Bourne, David W A, Klawitter, Jost, Sempio, Cristina, Chapman, Kevin, Knupp, Kelly, Wempe, Michael F., Borgelt, Laura, Christians, Uwe, Heard, Kennon, Bajaj, Lalit

Journal:

Clinical Toxicology (Informa Healthcare)

Année:

2019

Langue:

english

Fichier:

PDF, 798 KB

english, 2019

45

Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy

Wang, George Sam, Bourne, David W A, Klawitter, Jost, Sempio, Cristina, Chapman, Kevin, Knupp, Kelly, Wempe, Michael F., Borgelt, Laura, Christians, Uwe, Heard, Kennon, Bajaj, Lalit

Journal:

Clinical Toxicology (Informa Healthcare)

Année:

2019

Fichier:

PDF, 798 KB

2019

46

Temsirolimus Metabolic Pathways Revisited

Shokati, Touraj, Hartmann, Marcel, Davari, Baharak, Klawitter, Jost, Klawitter, Jelena, Christians, Uwe

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 1024 KB

english, 2019

47

Population Pharmacokinetic Modeling of Plasma Δ 9 ‐tetrahydrocannabinol and an Active and Inactive Metabolite Following Controlled Smoked Cannabis Administration

Sempio, Cristina, Huestis, Marilyn A., Mikulich‐Gilbertson, Susan K., Klawitter, Jost, Christians, Uwe, Henthorn, Thomas K.

Journal:

British Journal of Clinical Pharmacology

Année:

2019

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2019

48

Population Pharmacokinetic Modeling of Plasma Δ 9 ‐tetrahydrocannabinol and an Active and Inactive Metabolite Following Controlled Smoked Cannabis Administration

Sempio, Cristina, Huestis, Marilyn A., Mikulich‐Gilbertson, Susan K., Klawitter, Jost, Christians, Uwe, Henthorn, Thomas K.

Journal:

British Journal of Clinical Pharmacology

Année:

2019

Fichier:

PDF, 1.97 MB

2019

49

Surface Detection of THC Attributable to Vaporizer Use in the Indoor Environment

Sempio, Cristina, Lindley, Emily, Klawitter, Jost, Christians, Uwe, Bowler, Russell P., Adgate, John L., Allshouse, William, Awdziejczyk, Lauren, Fischer, Sarah, Bainbridge, Jacquelyn, Vandyke, Mike,

Journal:

Scientific Reports

Année:

2019

Fichier:

PDF, 1.13 MB

2019

50

Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy

Wang, George Sam, Bourne, David W. A., Klawitter, Jost, Sempio, Cristina, Chapman, Kevin, Knupp, Kelly, Wempe, Michael F., Borgelt, Laura, Christians, Uwe, Leonard, Jan, Heard, Kennon, Bajaj, Lalit

Journal:

Clinical Pharmacokinetics

Année:

2020

Fichier:

PDF, 684 KB

2020